ZANC.htm

NR ZANC

AU Guy,N.T.; Teillet,M.A.; Schuler,B.; Le Gal la Salle,G.; Le Douarin,N.; Naquet,R.; Batini,C.

TI Pattern of electroencephalographic activity during light induced seizures in genetic epileptic chicken and brain chimeras

QU Neuroscience Letters 1992 Sep 28; 145(1): 55-8

ER Neurosci Lett 1992 Nov 23;147(1):119

PT journal article

AB Genetic epilepsy was studied in Fayoumi epileptic (F.Epi) chickens and in neural chimeras obtained by selective substitution of embryonic brain vesicles of F.Epi donors in normal recipient chickens. Typical motor seizures accompanied by convulsions were evoked by intermittent light stimulation in F.Epi and in chimeras having embryonic substitution of the prosencephalon and the mesencephalon. The motor seizure was less severe in chimeras receiving only the prosencephalon. In the F.Epi, as well as in all the chimeras, the EEG during seizures was characterized by a desynchronized (or a flattening) pattern of activity. F.Epi and chimeras had a lower threshold to Metrazol induced seizures than control chickens. The experimental animals show that, in this model, large prosencephalic and mesencephalic areas are involved in the epileptic disease. The epileptic character of this genetic dysfunction is discussed.

AD Laboratoire de Physiologie de la Motricite, CNRS-URA 385, Paris, France.

SP englisch

PO Niederlande

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