ZDLY.htm

NR ZDLY

AU Joensen,H.; Sadler,C.L.; Ponte,J.; Yamamoto,Y.; Lindahl,S.G.; Eriksson,L.I.

TI Isoflurane does not depress the hypoxic response of rabbit carotid body chemoreceptors

QU Anesthesia and Analgesia 2000 Aug; 91(2): 480-5

PT journal article

AB Whether volatile anesthetics have an effect on the peripheral chemoreceptors is controversial, possibly because of differences in end-tidal CO(2) concentrations. We studied the effect of isoflurane on the hypoxic chemosensitivity of carotid body chemoreceptors at three different PaCO(2) levels before and during the administration of 1.0% isoflurane (0.5 minimum alveolar anesthetic concentration) in six normothermic New Zealand white rabbits anesthetized with thiopental. The response of the chemoreceptors was fitted to the equation: Frequency (Hz) = a + b x PaCO(2) + c x (1/PaO(2)) + Dx (1/PaO(2))(2). Mean values for the coefficients a, b, c and d for the control state were -4.5, 0.13, 771, and 6332, respectively. This relationship was not changed by addition of isoflurane at 1.0% end-tidal concentration (P = 0.40, analysis of variance). We conclude that isoflurane at 1.0% end-tidal concentration does not depress the hypoxic response of rabbit carotid body chemoreceptors during either hypo-, normo-, or hypercapnia. Implications: By measuring single-fiber chemoreceptor activity in anesthetized rabbits, we showed that isoflurane at 1.0% end-tidal concentration does not depress the hypoxic chemosensitivity of peripheral chemoreceptors during either hypo-, normo-, or hypercapnia in this species.

AD Department of Anesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden. henning.joensen@dadlnet.dk

SP englisch

PO USA

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