NR ZDQH

AU Sagara,M.; Haraguchi,M.; Yoshimura,N.; Yoshida,H.

TI Neuropathological changes induced by total cerebral ischemia (TCI) in a new experimental model

QU In Vivo 1993 Nov-Dec; 7(6A): 493-5

PT journal article

AB We describe a new model of human ischemia encephalopathy in rabbits by means of cross-clamping the ascending aorta in combination with blood exsanguination from the right atrium. Rabbit hippocampal CAI pyramidal cells and cerebellar Purkinje cells showed only a few changes in the early period after ischemia, but 4 days after ischemia a significant decrease in cell count and marked degeneration of the remaining cells were observed. When the pathological findings 4 days after TCI in the hippocampal area and cerebellar area were compared, the rate of cytoclasis was found to be significantly higher in the latter than in the former.

AD Department of Anesthesiology and Critical Care Medicine, Kagoshima University, Japan.

SP englisch

PO Griechenland

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