NR AACD
AU Adjou,K.T.; Demaimay,R.; Lasmezas,C.I.; Deslys,J.P.; Seman,M.; Dormont,D.
TI MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie
QU Antimicrobial Agents and Chemotherapy 1995 Dec; 39(12): 2810-2
IA http://aac.asm.org/cgi/reprint/39/12/2810?view=reprint&pmid=8593027
PT journal article
AB To test the efficacy of a new amphotericin B derivative, MS-8209, in delaying scrapie, hamsters were infected intracerebrally with the 263K scrapie agent and treated with MS-8209 either early in the course of the disease or continuously. The results show that (i) all treatments lengthened the incubation period of hamster scrapie, (ii) continuous treatment with MS-8209 doubled the length of the incubation period compared with that observed in infected, untreated animals, and (iii) all treatments delayed the accumulation of a proteinase-resistant prion protein and glial fibrillary acidic protein in the brain. These findings suggest that MS-8209 is a powerful tool for investigating the pathogenesis of transmissible subacute spongiform encephalopathies.
ZR 15 Zitate
MH Amphotericin B/*analogs & derivatives/therapeutic use; Animals; Central Nervous System/drug effects/metabolism; Cricetinae; Female; Glial Fibrillary Acidic Protein/biosynthesis; Mesocricetus; PrPsc Proteins/biosynthesis; Research Support, Non-U.S. Gov't; Scrapie/*drug therapy/metabolism
AD Department de la Recherche Medicale, Commissariat a l'Energie Atomique, Fontenay aux Roses, Paris, France.
SP englisch
PO USA