NR AACP
AU Aguglia,U.; Oliveri,R.L.; Gambardella,A.; Quattrone,A.
TI Functional integrity of benzodiazepine receptors of the geniculo-striate visual pathways in Creutzfeldt-Jakob disease. A pharmacological evoked potential study.
QU Journal of Neurology. Zeitschrift für Neurologie 1993 Jan; 240(1): 25-7
PT journal article
AB We evaluated the effects of flumazenil (FMZ), a high-affinity benzodiazepine receptor antagonist, on flash-evoked visual potentials (FEPs) in a patient with Creutzfeldt-Jakob disease (CJD). FEPs were recorded in three different consecutive sessions: (1) basal condition, without any pharmacological treatment; (2) 3.5 min after i.v. administration of 5 mg FMZ; (3) 1 min after i.v. administration of 10 mg diazepam (DZP). FMZ provoked a marked increase in the amplitude as well as evident shortening of the latency of early FEP components. DZP reversed these effects. These results are in agreement with our previous findings of anatomical and functional integrity of the geniculo-striate pathways in human CJD and demonstrate functional integrity of benzodiazepine receptors in this visual system in CJD.
MH Case Report; Creutzfeldt-Jakob Syndrome/*physiopathology; Diazepam/pharmacology; Evoked Potentials, Visual/*drug effects/physiology; Flumazenil/pharmacology; Human; Male; Middle Age; Reaction Time; Receptors, GABA-A/*physiology; Visual Cortex/*physiopathology
AD Institute of Neurological Sciences, School of Medicine, University of Reggio Calabria Catanzaro, Italy.
SP englisch
PO Deutschland