NR AACR
AU Aguglia,U.; Farnarier,G.; Regis,H.; Oliveri,R.L.; Quattrone,A.
TI Sensory evoked potentials in Creutzfeldt-Jakob disease
QU European Neurology 1990; 30(3): 157-61
PT journal article
AB Eight patients presenting with intermediate or terminal evolution of Creutzfeldt-Jakob disease (CJD) were investigated by means of evoked potentials. Fifteen age-matched healthy subjects served as controls. The 8 patients had well-recognizable but simplified flash evoked potentials (FEPs) consisting of P1 and N2 waves followed by a single late positive (P2) deflection. Enlarged FEPs were found in 2 of the 8 patients. The somatosensory central conduction time was normal in 3 of 5 patients, and it resulted in upper normal limits or was moderately slowed in 2 patients. No enlarged somatosensory scalp potentials were recorded. Cortical somatosensory responses were characterized by an unrecognizable (4 patients) or delayed (2 patients) N33 wave. Brainstem auditory evoked responses, recorded in 6 patients, were normal. In CJD very important functional impairment of the sensory cortical areas is associated with absent or mild dysfunction of the subcortical sensory pathways.
MH Acoustic Stimulation; Aged; Brain/*physiopathology; Creutzfeldt-Jakob Syndrome/*physiopathology; Electric Stimulation; *Evoked Potentials, Auditory; *Evoked Potentials, Somatosensory; *Evoked Potentials, Visual; Female; Human; Male; Middle Age; Photic Stimulation
AD Istituto di Scienze Neurologiche, Universita di Reggio Calabria, Catanzaro, Italia.
SP englisch
PO Schweiz