NR AACV
AU Aguzzi,A.; Glatzel,M.; Montrasio,F.; Prinz,M.; Heppner,F.L.
TI Interventional strategies against prion diseases
QU Nature Reviews. Neuroscience 2001 Oct; 2(10): 745-9
PT journal article; review; review, tutorial
AB Only a few years ago, the idea that transmissible spongiform encephalopathies could be treated pharmacologically would have met with considerable scepticism. Even now, there is no way to cure a patient or animal suffering from a manifest prion disease. But recent, exciting developments seem to indicate that immunological and pharmacological interventions could have some potential for the pre-exposure and post-exposure prophylaxis of prion diseases. Although it is unlikely that we will be able to cure the clinically overt stages of prion diseases in the foreseeable future, palliative and even life-prolonging interventions might no longer be confined to the realm of science fiction.
ZR 52
MH Animal; Human; Palliative Care; PrPsc Proteins/drug effects/metabolism; Prion Diseases/prevention & control/*therapy; Support, Non-U.S. Gov't
AD Institute of Neuropathology, Universitätsspital Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland. adriano@pathol.unizh.ch
SP englisch
PO England