NR AATI
AU Armstrong,R.A.; Cairns,N.J.; Lantos,P.L.
TI The spatial pattern of the vacuolation in patients with sporadic Creutzfeldt-Jakob disease
QU Neuroscience Letters 2000 Mar 10; 281(2-3): 187-90
PT journal article
AB 1600 microm in diameter and, in the majority of tissue sections, the vacuole clusters were distributed with regular periodicity parallel to the tissue boundary. The size of the vacuole clusters was positively correlated with patient age in the lower laminae of the occipital cortex and the inferior temporal gyrus (ITG) and negatively correlated with age in the hippocampus. In addition, the size of the vacuole clusters was positively correlated with disease duration in the upper laminae of the ITG. The size and distribution of the vacuole clusters suggests that the vacuolation in CJD reflects the degeneration of specific brain pathways and supports the hypothesis that prion pathology may spread through the brain along well defined anatomical pathways.
MH Aged; Brain/metabolism/*pathology/ultrastructure; Cerebellum/metabolism/pathology; Cerebral Cortex/metabolism/pathology; Creutzfeldt-Jakob Syndrome/metabolism/*pathology; Female; Hippocampus/metabolism/pathology; Human; Male; Middle Age; Prions/metabolism; Vacuoles/metabolism/*pathology
AD R. A. Armstrong (r.a.armstrong@aston.ac.uk), Vision Sciences, Aston University, Birmingham B4 7ET, UK; P. L. Lantos, N. J. Cairns, Brain Bank, Department of Neuropathology, Institute of Psychiatry, King's College, London, SE5 8AF, UK
SP englisch
PO Irland