NR AAVT
AU Autret,A.; Henry-Le Bras,F.; Duvelleroy-Hommet,C.; Lucas,B.; de Toffol,B.
TI [Agrypnia (organic insomnia)]
OT Les agrypnies
QU Neurophysiologie Clinique 1995; 25(6): 360-6
PT journal article; review; review, tutorial
AB The word agrypnia, ie, organic insomnia, was first used to describe a patient with a Morvan fibrillary chorea, which is an ill-delineated syndrome. This review considers the experimental insomnia created by raphe nuclei, anterior hypothalamic, or thalamic lesions. There are some papers reporting REM and non-REM sleep reduction in man after vascular, traumatic or degenerative lesion of the pons. There is only one case of agrypnia due to a bilateral stereotatic thalamic injury. Infectious agrypnia (trypanosomiasis, Von Economo) may exist but has not been documented by polygraphic means. Fatal familial insomnia induces a precocious agrypnia and leads to death with vegetative and motor disturbances. It is associated with an abnormal prion-protein which may interfere with gabaergic synapses. Finally agrypnia in humans corresponds to either lesionnal or infra microscopic synaptic prion linked disorders.
ZR 37
MH Animal; Brain Diseases/*complications; Brain Injuries/complications; Chorea/complications; English Abstract; Human; Infection/complications; Nerve Degeneration/physiology; Prion Diseases/complications; Sleep Initiation and Maintenance Disorders/*etiology; Vascular Diseases/complications
AD Clinique neurologique, CHU Bretonneau, Tours, France.
SP französisch
PO Niederlande