NR ABAK
AU Barriga,F.; Ruiz-Dominguez,J.A.; Velayos,J.L.
TI [Familial fatal insomnia: a human prion disease which opens the door to a greater understanding of the thalamus]
OT Insomnio familiar fatal: una enfermedad prionica humana que abre las puertas a un mayor conocimiento del talamo.
QU Revista de Medicina de la Universidad de Navarra 1997 Oct-Dec; 41(4): 224-8
PT journal article; review; review, tutorial
AB In 1986, Lugaresi [1] described fatal familial insomnia (FFI), an inherited prion disease, characterised by untreatable insomnia and dysautonomia. The most severe neuropathological changes have been found in the mediodorsal (MD) and anterior (A) thalamic nuclei. The data lead to think that the thalamus could play an important role in the wake-sleep cycle and other vegetative and endocrine circadian activities, specially MD and A.
ZR 24
MH Adult; Animal; Cats; Circadian Rhythm/*physiology; Codon/genetics; English Abstract; Female; Genes, Dominant; Gliosis/etiology/pathology; Human; Male; Middle Age; Neurons/pathology; PrPc Proteins/genetics; Prion Diseases/complications/genetics/pathology/*physiopathology; Sleep/*physiology; Sleep Initiation and Maintenance; Disorders/etiology/genetics/pathology/*physiopathology; Support, Non-U.S. Gov't; Thalamic Nuclei/pathology/*physiopathology
AD Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid.
SP spanisch
PO Spanien