NR ABBF
AU Bassant,M.H.; Court,L.; Cathala,F.
TI Impairment of the cortical and thalamic electrical activity in scrapie-infected rats
QU Electroencephalography and Clinical Neurophysiology 1987 Mar; 66(3): 307-16
PT journal article
AB Cortical and thalamic EEG and somatosensory evoked potential (SEP) induced by stimulation of the somesthetic radiations were studied in scrapie-infected rats. Animals were inoculated intracerebrally with a rat-adapted strain (originating in the C506 M3 mouse scrapie strain). EEG and SEP were recorded from 9 to 17 months after inoculation (ti). Abnormalities (paroxysmal bursts, isolated spikes) first occurred in the cortex (parietal areas) and later in the thalamus, where they were usually less marked. Latencies of the postsynaptic components of the SEP increased at ti + 9 months. This effect became progressively more pronounced and at ti + 15 months, latencies of presynaptic components were also delayed. Nevertheless, marked alteration of the SEP occurred only at the terminal stage of the disease. These findings show that the scrapie-induced disturbances affect more especially the cortex. Decrease of inhibitory processes as well as electronic coupling between cells, resulting from the virus-induced membrane fusion, could produce paroxysmal activity of EEG and SEP impairments.
IN Intracerebral mit Rattenscrapie infizierte Ratten zeigten per EEG bereits 9 bis 17 Monate nach der Inokulation anfallartige Ausbrüche und isolierte Spitzen zunächst in der Hirnrinde und später sowie weniger ausgeprägt auch im Thalamus. Ab dem 9. Monat nach der Infektion nahmen die Reaktionszeiten der postsynaptischen Elemente immer mehr zu und erst nach 15 Monaten wurde auch bei den präsynaptischen Elementen eine Verzögerung gemessen.
MH Animal; Electroencephalography; *Evoked Potentials, Somatosensory; Male; Rats; Rats, Inbred Strains; Rodent Diseases/*physiopathology; Scrapie/*physiopathology; Support, Non-U.S. Gov't; Thalamic Nuclei/physiopathology
SP englisch
PO Irland