NR ABBG

AU Bassant,M.H.; Baron,H.; Gumpel,M.; Cathala,F.; Court,L.

TI Spread of scrapie agent to the central nervous system: study of a rat model.

QU Brain Research 1986 Sep 24; 383(1-2): 397-401

PT journal article

AB Invasion of scrapie agent into the central nervous system (CNS) was studied in rats following intracerebral and peripheral inoculation, the latter by injection into intact or transected sciatic nerve. Comparison of sleep-wakefulness alterations, neuropathological features, and time lag of electroencephalographic and clinical signs in the 3 groups suggests that hematogenous spread of infection to the CNS may predominate over neural transport, and that peripheral inoculation may closely approximate natural infection.

MH Animal; Brain/pathology; Central Nervous System/*microbiology; Electroencephalography; Male; Peripheral Nerves/*microbiology; *Prions; Rats; Rats, Inbred Strains; Scrapie/*microbiology/pathology/physiopathology; Sleep/physiology; Support, Non-U.S. Gov't

SP englisch

PO Niederlande

OR Prion-Krankheiten 1

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