NR ABDW
AU Beekes,M.; McBride,P.A.
TI Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie
QU Neuroscience Letters 2000 Jan 14; 278(3): 181-4
PT journal article
AB Infection of the central nervous system (CNS) is a defining feature of scrapie. Several findings suggest that scrapie agent invades the CNS via the splanchnic and vagus nerve after ingestion of infectivity. Here we address the involvement of the enteric nervous system (ENS) and gut-associated lymphoid tissue (GALT) in this pathogenetic process. Immunocytochemistry was used for the detection of pathological PrP in the duodenum and ileum of hamsters fed with 263K scrapie and sacrificed at different stages of incubation. The experiments revealed early infection of various GALT components and of submucosal and myenteric ENS ganglia. These results provide evidence for an important role of the ENS in scrapie neuroinvasion and for centripetal vagal spread of infection from the gut to the brain after oral uptake of agent.
MH Administration, Oral; Animal; Duodenum/metabolism; Enteric Nervous System/*metabolism; Ganglia, Sympathetic/metabolism; Hamsters; Ileum/metabolism; Intestines/*metabolism; Lymphoid Tissue/*metabolism; Mesocricetus; Myenteric Plexus/metabolism; Prions/*metabolism; Scrapie/*metabolism/transmission; Submucous Plexus/metabolism; Support, Non-U.S. Gov't
AD Michael Beekes (beekesm@rki.de), Robert Koch-Institut (P31), Nordufer 20, 13353 Berlin, Germany; Patricia A. McBride (tricia.mcbride@bbsrc.ac.uk), Institute for Animal Health, BBSRC and MRC, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK
SP englisch
PO Irland