NR ABER
AU Bell,J.D.; Cox,I.J.; Williams,S.C.R.; Belton,P.S.; McConnell,I.; Hope,J.
TI In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy
QU Journal of General Virology 1991 Oct; 72(10): 2419-23
PT journal article
AB In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.
MH Animal; Central Nervous System/*metabolism; Disease Models, Animal; Magnetic Resonance Spectroscopy; Mice; Perchloric Acid/chemistry/metabolism; Scrapie/*metabolism; Support, Non-U.S. Gov't
AD NMR Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
SP englisch
PO England