NR ABGC
AU Benvenga,S.; Campenni,A.; Facchiano,A.
TI Internal repeats of prion protein and A beta PP, and reciprocal similarity with the amyloid-related proteins
QU Amyloid 1999 Dec; 6(4): 250-5
PT journal article
AB We are currently interested in a group of proteins associated with the dementias characterized by amyloid deposition in the brain: amyloid beta protein precursor (A beta PP) of Alzheimer's disease (AD) and the abnormal isoform of prion protein (PrP) of spongiform encephalopathies such as kuru, Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSSD). Here we show that both A beta PP and prion protein (PrP) consist of peculiar internal repeats and share regions of sequence similarity. Further analysis revealed that local homology is also shared with the other proteins involved in specific forms of amyloidosis - i.e., the amyloid related proteins (ARP).
MH Amino Acid Sequence; Amyloid beta-Protein Precursor/*chemistry; Human; Molecular Sequence Data; Prion Diseases/metabolism; Prions/*chemistry; *Repetitive Sequences, Amino Acid; Sequence Alignment; Sequence Homology, Amino Acid
AD Cattedra and Divisione di Endocrinologia, Policlinico Universitario di Messina, Italy.
SP englisch
PO USA