NR ABLG
AU Boller,F.; Lopez,O.L.; Moossy,J.
TI Diagnosis of dementia: clinicopathologic correlations.
QU Neurology 1989 Jan; 39(1): 76-9
KI Neurology. 1989 Nov; 39(11): 1559-60. PMID: 2624647
PT journal article
AB Based on 54 demented patients consecutively autopsied at the University of Pittsburgh, we studied the accuracy of clinicians in predicting the pathologic diagnosis. Thirty-nine patients (72.2%) had Alzheimer's disease, while 15 (27.7%) had other CNS diseases (four multi-infarct dementia; three Creutzfeldt-Jakob disease; two thalamic and subcortical gliosis; three Parkinson's disease; one progressive supranuclear palsy; one Huntington's disease; and one unclassified). Two neurologists independently reviewed the clinical records of each patient without knowledge of the patient's identity or clinical or pathologic diagnoses; each clinician reached a clinical diagnosis based on criteria derived from those of the NINCDS/ADRDA. In 34 (63%) cases both clinicians were correct, in nine (17%) one was correct, and in 11 (20%) neither was correct. These results show that in patients with a clinical diagnosis of dementia, the etiology cannot be accurately predicted during life.
MH Adult; Aged; Aged, 80 and over; Alzheimer Disease/diagnosis/pathology; Brain/*pathology; Creutzfeldt-Jakob Syndrome/diagnosis/pathology; Dementia/*diagnosis/pathology; Dementia, Multi-Infarct/diagnosis/pathology; Diagnostic Errors; Female; Human; Male; Middle Age; Nerve Degeneration; Nervous System Diseases/diagnosis/pathology; Parkinson Disease/diagnosis/pathology; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.
AD Department of Neurology, Veterans Administration Medical Center, Pittsburgh, PA.
SP englisch
PO USA