NR ABNC
AU Borras,M.T.; Merendino,J.J.Jr.; Gibbs,C.J.Jr.
TI Molecular hybridization studies with scrapie brain nucleic acids. II. Differential expression in scrapie hamster brain.
QU Archives of Virology 1986; 88(1-2): 79-90
PT journal article
AB RNA and DNA fractions prepared from nucleic acids obtained from normal and scrapie-infected hamster brains following exhaustive treatment with nuclease were used as probes in a search for a specific scrapie nucleic acid. Employing RNA blot hybridization a 2.3 Kb RNA was detected in higher concentration in scrapie-infected hamster brains than in normal controls. Our data suggests that scrapie disease may be associated with the differential expression of a series of host genes.
MH Animal; Brain/*microbiology; DNA/analysis; DNA, Viral/*analysis; Female; Hamsters; Mesocricetus; *Nucleic Acid Hybridization; Prions/*genetics/pathogenicity; RNA, Viral/*analysis; RNA-Directed DNA Polymerase/analysis; Sequence Homology, Nucleic Acid
AD Teresa Borrás, J.J.Merendino Jr. and C.J.Gibbs Jr., Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A.
SP englisch
PO Österreich