NR ABOC
AU Bousset,L.; Melki,R.
TI Similar and divergent features in mammalian and yeast prions
QU Microbes and Infection 2002 Apr; 4(4): 461-9
PT journal article; review; review, tutorial
AB Mammalian transmissible spongiform encephalopathies are likely due to the propagation of an abnormal form of a constitutive protein instead of traditional genetic material (nucleic acids). Such infectious proteins, which are termed prions, exist in yeast. They are at the origin of a number of phenotypes that are inherited in a non-Mendelian manner. These prions are very useful to dissect the molecular events at the origin of this structure-based inheritance. The properties of mammalian and yeast prions are presented and compared. This review highlights a number of similarities and differences.
ZR 110
MH Amino Acid Sequence; Animal; Comparative Study; Human; Mammals/genetics; Molecular Chaperones/metabolism; Prions/*chemistry/classification/genetics/*metabolism; Protein Conformation; Species Specificity; Support, Non-U.S. Gov't; Yeasts/*chemistry/genetics
AD Laboratoire d'enzymologie et biochimie structurales, CNRS, Bat. 34, avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
SP englisch
PO Frankreich