NR ABQX
AU Bredehorn,T.; Wilhelm,F.; Wiederhold,C.; Duncker,G.I.
TI [Incidence of potential transmitters of Creutzfeldt-Jakob disease. A study of a collective of potential cornea donors]
OT Häufigkeit von potenziellen Überträgern der Creutzfeldt-Jakob-Krankheit. Untersuchung eines Kollektivs von potenziellen Hornhautspendern.
QU Ophthalmologe 2001 Mar; 98(3): 269-72
PT journal article
AB BACKGROUND: The prevalence of Creutzfeldt-Jakob disease (CJD) is 1.5 cases per million persons. In addition to familial and sporadic forms, fewer than 5% of cases are due to iatrogenic transmission. Corneal transplantation has clearly been implicated as the origin of CJD in four cases. MATERIALS AND METHODS: We examined possible risks factors for corneal transplantation in material from 2545 deceased patients at the University Hospital of Halle. RESULTS: Two patients had died of CJD or slow virus disease. Also in the 109 identified as being at higher risk of CJD no organs or tissues were harvested. CONCLUSION: We strongly recommend that patients at higher risk group of CJD, patients dying of CNS diseases of unknown origin and cause, and patients dying in psychiatric clinics be excluded from donating organ and tissue.
MH Adult; Animal; Autopsy; Comparative Study; Corneal Transplantation/*adverse effects; Creutzfeldt-Jakob Syndrome/*transmission; English Abstract; Female; Human; Incidence; Male; Middle Age; Risk Factors; *Tissue Donors
AD Universitätklinik und Poliklinik für Augenheilkunde, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Strasse 8, 06097 Halle/Saale. timm.bredehorn@dso.de
SP deutsch
PO Deutschland
OR Prion-Krankheiten 2