NR ABRX
AU Brown,D.A.; Belichenko,P.V.; Sales,J.; Jeffrey,M.J.; Fraser,J.R.
TI Early loss of dendritic spines in murine scrapie revealed by confocal analysis
QU Neuroreport 2001 Jan 22; 12(1): 179-83
PT journal article
AB Confocal analysis of dye-filled neurons has revealed a significant early loss of dendritic spines in a murine scrapie model in which neuron loss occurs in the hippocampus. An 18% loss of spines was found at 109 days, > 50 days before neuron loss occurs, and by 126 days a 51% spine loss was found. Spine loss is concurrent with synapse loss, axon terminal degeneration and a decrease in long term potentiation in this model. Preceding these changes is the deposition of disease specific PrP at 70 days, which may initiate the damage to dendritic spines and the subsequent degeneration of synapses. We suggest that these changes underlie the development of clinical disease in the transmissible spongiform encephalopathies.
MH Animal; Cell Count; Dendrites/*pathology; Mice; Mice, Inbred C57BL; Microscopy, Confocal/methods; Pyramidal Cells/*pathology; Scrapie/*pathology
AD Debbie A. Brown (debbie.brown@bbsrc.ac.uk), Janet R. Fraser (janet.fraser@bbsrc.ac.uk), Institute for Animal Health, BBSRC and MRC, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK; ; Pavel V. Belichenko, Brain Research Institute, Russian Academy of Medical Science, Moscow, Russia; Jill Sales, Napier University, Merchiston Campus, Colinton Road, Edinburgh EH10 5DT; Martin J. Jeffrey (m.jeffrey@vla.maff.gov.uk), VLA Lasswade Veterinary Laboratory, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 OPZ, Scotland, UK
SP englisch
PO England