NR ABVC
AU Brown,P.
TI Infectious cerebral amyloidosis: clinical spectrum, risks and remedies.
QU Developments in Biological Standardization 1993; 80: 91-101
PT journal article; review; review, tutorial
AB The clinical and pathological features of the NIH series of 209 transmitted cases of sporadic Creutzfeldt-Jakob disease (CJD) are compared with familial and iatrogenic forms of spongiform encephalopathy. Real or potential risk factors are noted, including animal sources such as scrapie and BSE, iatrogenic sources such as homografts and cadaveric tissue extracts, and genetic defects in the chromosome 20 amyloid precursor gene. The paper concludes with a discussion of the means by which such risks may be minimized.
ZR 20
MH Amyloidosis/epidemiology/genetics/*microbiology/pathology; Animal; Cohort Studies; Comparative Study; Creutzfeldt-Jakob; Syndrome/epidemiology/ethnology/genetics/microbiology/pathology/*transmiss; ion; Drug Contamination; Female; Food Contamination; Gerstmann-Sträussler-Scheinker Disease/pathology; Human; Iatrogenic Disease; Kuru/pathology; Male; Meat/adverse effects; Middle Age; Organ Specificity; Pedigree; Prion Diseases/prevention & control; Risk Factors; Transplantation/adverse effects; Zoonoses
AD Paul Brown (pwb@codon.nih.gov), Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
SP englisch
PO Schweiz