NR ABVS
AU Brown,P.; Jannotta,F.; Gibbs,C.J.Jr.; Baron,H.; Guiroy,D.C.; Gajdusek,D.C.
TI Coexistence of Creutzfeldt-Jakob disease and Alzheimer's disease in the same patient
QU Neurology 1990 Feb; 40(2): 226-8
PT journal article
AB We report the case of a 73-year-old patient in whom a diagnosis of Creutzfeldt-Jakob disease, suggested by the clinical course, was verified by the neuropathologic finding of widespread spongiform change and astrogliosis, the presence of proteinase-resistant protein in brain extracts, and the experimental transmission of spongiform encephalopathy to primates inoculated with brain tissue. However, neuropathologic examination also revealed a profusion of senile and neuritic plaques and neurofibrillary tangles that reacted with antibody to the amyloid beta-protein characteristic of Alzheimer's disease, but not with antibody to the scrapie amyloid protein characteristic of Creutzfeldt-Jakob disease.
MH Aged; Alzheimer Disease/*complications/pathology; Case Report; Creutzfeldt-Jakob Syndrome/*complications/pathology; Female; Human
AD Paul Brown (pwb@codon.nih.gov), Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
SP englisch
PO USA