NR ABWO
AU Brown,P.; Salazar,A.M.; Gibbs,C.J.Jr.; Gajdusek,D.C.
TI Alzheimer's disease and transmissible virus dementia (Creutzfeldt-Jakob disease)
QU Annals of the New York Academy of Sciences 1982; 396: 131-43
PT journal article
AB Ample justification exists on clinical, pathologic, and biologic grounds for considering a similar pathogenesis for AD and the spongiform virus encephalopathies. However, the crux of the comparison rests squarely on results of attempts to transmit AD to experimental animals, and these results have not as yet validated a common etiology. Investigations of the biologic similarities between AD and the spongiform virus encephalopathies proceed in several laboratories, and our own observation of inoculated animals will be continued in the hope that incubation periods for AD may be even longer than those of CJD.
MH Adult; Aged; Alzheimer Disease/genetics/*pathology/transmission; Animal; Autopsy; Biopsy; Brain/*pathology; Case Report; Comparative Study; Creutzfeldt-Jakob Syndrome/genetics/*pathology/transmission; Dementia/*pathology; Female; Human; Male; Middle Age; Primates; Scrapie/pathology; Sheep
AD Paul Brown, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
SP englisch
PO USA