NR ABWS
AU Brown,P.; Cathala,F.; Gajdusek,D.C.
TI Creutzfeldt-Jakob disease in France: III. Epidemiological study of 170 patients dying during the decade 1968-1977.
QU Annals of Neurology 1979 Nov; 6(5): 438-46
PT journal article
AB Systematic search for Creutzfeldt-Jakob disease (CJD) in France yielded a total of 170 patients dying between 1968 and 1977. The overall annual mortality rate from CJD for France was 0.32 case per million persons, with by far the highest rate (1.33 cases per million) in the most densely populated parts of Paris. A highly significant correlation between population density and the mortality rate of CJD in the Paris urban agglomeration was consistent with the hypothesis of human-to human disease transmission, although in the rest of France CJD occurred at equally low rates among rural and urban populations. Temporospatial case clustering was not observed, nor could occupation, surgery, or potential exposure to scrapie be associated with an increased risk of contracting CJD. Six to 9% of cases were familial, analysis of which discouraged the notion of a familial "common exposure" in favor of genetic transmission of susceptibility to the virus or of the virus itself. A prospective epidemiological study or newly occurring cases of CJD, especially familial and geographically isolated cases, is being undertaken in the hope of identifying the means by which CJD is naturally acquired.
IN
Eine systematische Suche, vermutlich in Akten, lieferte für Frankreich in den Jahren 1968-1977 nur 170 Creutzfeldt-Jakob-Fälle. Damit lag die CJD-Inzidenz insgesamt bei 0,32/1 Million Einwohner und Jahr, aber in den anscheinend besser erfassten dicht besiedelten Teilen der Hauptstadt Paris bei 1,33. Eine Mensch-zu-Mensch-Übertragung als Ursache für diese Häufung ist aber auch nicht auszuschließen. 6-9% der Fälle waren offensichtlich familiär, also entweder erblich bedingt oder erblich begünstigt.
Laut Will und Matthews [AMOQ,1982] soll dieser Artikel einen Fall von Creutzfeldt-Jakob-Krankheit bei einem genetisch unabhängigen ? also eingeheirateten oder adoptierten - Mitglied einer Creutzfeldt-Jakob-Familie beschreiben.
MH Age Factors; Aged; Creutzfeldt-Jakob Syndrome/*epidemiology/genetics/mortality; Female; France; Germany/ethnology; Greece/ethnology; Human; Male; Paris; Risk; Sex Factors; Tunisia/ethnology; Urban Population
SP englisch
PO USA