NR ABWU
AU Brown,P.; Cathala,F.
TI Creutzfeldt-Jakob disease in France: I. Retrospective study of the Paris area during the ten-year period 1968-1977.
QU Annals of Neurology 1979 Feb; 5(2): 189-92
PT journal article
AB A systematic search for cases of Creutzfeldt-Jakob disease occurring in the ten-year period 1968 through 1977 was conducted in the city of Paris and surrounding departments which comprise the greater Paris area. Fifty-six cases were found among the total population of approximately 10 million inhabitants, with a maximum incidence of 1.1 cases per year per million people in the densely populated city of Paris and a progressively lower incidence in the less heavily populated suburban and rural areas of the region. There was no temporal or geographic clustering of disease. Attention is drawn to the often rapid onset and short duration of illness (nearly two-thirds of the patients died within five months of onset) and the frequent early occurrence of symptoms such as asthenia, diaphoresis, and disturbances of sleep and appetite.
IN In dem Jahrzehnt 1968-1977 wurden in Paris und Umgebung bei 10 Millionen Einwohnern nur 56 pathologisch bestätigte Fälle von Creutzfeldt-Jakob-Krankheit registriert. Die maximale Inzidenz von 1,1 pro Million Einwohner und Jahr fand man in der dicht besiedelten City und mit abnehmender Wohndichte nahm auch die CJD-Inzidenz ab. 2/3 der Fälle führten binnen 5 Monaten zum Tode. Häufig wurden als erste Symptome Asthenie (Kraftlosigkeit und schnelle Ermüdung), Diaphorrese (verstärktes Schwitzen) und Störungen von Schlaf und Apetit beobachtet.
MH Adult; Aged; Creutzfeldt-Jakob Syndrome/diagnosis/*epidemiology/mortality; Female; France; Human; Male; Middle Age; Paris; Retrospective Studies; Space-Time Clustering; Support, U.S. Gov't, P.H.S.; Time Factors
SP englisch
PO USA