NR ABZQ
AU Budka,H.; Aguzzi,A.; Brown,P.; Brucher,J.M.; Bugiani,O.; Collinge,J.; Diringer,H.; Gullotta,F.; Haltia,M.; Hauw,J.J.; Ironside,J.W.; Kretzschmar,H.A.; Lantos,P.L.; Masullo,C.; Pocchiari,M.; Schlote,W.; Tateishi,J.; Will,R.G.
TI Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases)
QU Brain Pathology 1995 Jul; 5(3): 319-22
KI Brain Pathol. 1996 Apr;6(2):197-8. PMID: 8737933
PT consensus development conference; journal article; review
AB Despite many sensational and intimidating reports in the mass media, transmissible spongiform encephalopathies (prion disease) are not contagious in the usual sense. Successful transmission requires both specific material (an affected individual's tissue, from or adjacent to CNS) and specific modes (mainly penetrating contact with the recipient). Nevertheless, specific safety precautions are mandatory to avoid accidental transmission and to decontaminate any infectivity. Autopsy is essential for definite diagnosis of these disorders. Recommendations are given here for performance of the autopsy, for neuropathology service and appropriate decontamination; they are based on the current literature and on precautions taken in most laboratories with experience in handling tissue from transmissible spongiform encephalopathies. In particular, special care must be taken to avoid penetrating wounds, possible contamination should be kept to a minimum, and potential infectious material must be adequately decontaminated by specific means.
IN Die Autoren behaupten, die Prion-Krankheiten seien nur infektiös, wenn infektiöses Material aus dem Gehirn oder angrenzendem Gewebe direkt ins ein anderes Tier gelangt. Von infektiösen Weiden haben sie wohl noch nichts gehört. Der Artikel soll Sicherheitsmaßnahmen beschreiben.
ZR 20
MH Autopsy; Creutzfeldt-Jakob Syndrome/pathology/*transmission; Decontamination; Human; Prion Diseases/pathology/*transmission; *Safety; *Specimen Handling
AD Institute of Neurology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
SP englisch
PO Schweiz
OR Prion-Krankheiten 2