NR ACAD
AU Bundza,A.
TI Experimental scrapie in white Swiss mice
QU Zentralblatt für Veterinärmedizin, Reihe B - Journal of Veterinary Medicine, Series B 1990 Dec; 37(10): 777-80
PT journal article
AB In order to confirm the clinical and histological diagnosis of scrapie and to determine the infectivity titer of the scrapie agent in the brain of a naturally infected Suffolk sheep, 123 white Swiss mice were inoculated intracerebrally. From about 13 to 20 months post-inoculation, 28 mice died, and 95 that were sick were killed. In the terminal stages of disease, the mice developed weakness, gradual emaciation, posterior ataxia, and occasionally alopecia. The average infection (83%) of mice affected with scrapie occurred in groups 1 to 4 inoculated with dilution 10(-1) to 10(-4) of scrapie sheep brain. Sixty-seven (54.5%) of the mice developed spongiform lesions and vacuolar degeneration of neurons. Similarities of scrapie with other subacute spongiform encephalopathies in animals and humans are discussed.
MH Animal; Biological Assay; Brain/*microbiology; Mice; Scrapie/*diagnosis/pathology; Sheep
AD Agriculture Canada, Animal Diseases Research Institute, Nepean.
SP englisch
PO Deutschland