NR ACDB
AU Buyukmihci,N.C.; Rorvik,M.; Marsh,R.F.
TI Replication of the scrapie agent in ocular neural tissues
QU Proceedings of the National Academy of Sciences of the United States of America 1980 Feb; 77(2): 1169-71
PT journal article
AB Optic nerves and retinas removed from hamsters experimentally inoculated with the scrapie agent contain a high titer of infectivity. Ophthalmoscopic examination of these animals revealed gross lesions of retinopathy as early as 3 weeks before the onset of clinical signs of brain degeneration. These results suggest that the scrapie agent may spread centrifugally in nerve fibers after intracerebral inoculation and that the scrapie-associated retinopathy seen in hamsters is directly induced by the agent rather than the result of retrograde degeneration from central neural damage.
MH Animal; Brain/microbiology; Hamsters; Male; Optic Nerve/*microbiology; Prions/*growth & development; Retina/*microbiology/ultrastructure; Scrapie/*microbiology; Sheep; Support, U.S. Gov't, P.H.S.; Time Factors; *Virus Replication
SP englisch
PO USA