NR ACFO
AU Carlson,G.A.; Hsiao,K.; Oesch,B.; Westaway,D.; Prusiner,S.B.
TI Genetics of prion infections
QU Trends in Genetics 1991 Feb; 7(2): 61-5
PT journal article; review; review, tutorial
AB Although the infectious prions causing scrapie and several human transmissible neurodegenerative diseases resemble viruses in many respects, molecular and genetic analyses indicate that prions are fundamentally different from viruses in their structure and the mechanisms by which they cause disease. The only macromolecule that has been identified in infectious prion preparations is a disease-specific isoform of the prion protein, which is encoded by a host gene. A growing body of data supports the contention that prion infections represent a novel host-pathogen interaction.
IN Ein Review, der mutierte Prionproteine und nicht Viren als wahrscheinliche Überträger von Scrapie und den entsprechenden menschlichen Krankheiten beschreibt.
ZR 41
MH Animal; Host-Parasite Relations/genetics; Human; Linkage (Genetics); Prions/*genetics; Scrapie/*genetics; Support, U.S. Gov't, P.H.S.
AD McLaughlin Research Institute, Great Falls, MT 59401.
SP englisch
PO England