NR ACHF
AU Cartier,L.R.; Verdugo,R.; Vergara,C.; Galvez,S.
TI The nucleus basalis of Meynert in 20 definite cases of Creutzfeldt-Jakob disease
QU Journal of Neurology, Neurosurgery and Psychiatry 1989 Mar; 52(3): 304-9
PT journal article
AB The population of neurons and the neuronal size in the nucleus basalis of Meynert (nbM) were studied in 20 patients with definite Creutzfeldt-Jakob disease (CJD). When compared with a normal control group, the 20 CJD brains showed a significant loss of neurons and reduction of neuronal size, mainly in the middle level of the nbM and mostly affecting the right side. Since these findings show some parallelism with the amount of cortical damage and given the scarce gliosis and spongiosis found in only six of the 20 CJD brains, we postulate that the involvement of the nbM in CJD is a retrograde abnormality secondary to the damage of the neocortex.
MH Adult; Aged; Basal Ganglia/*pathology; Cell Count; Cerebral Cortex/pathology; Creutzfeldt-Jakob Syndrome/*pathology; Female; Human; Male; Middle Age; Nerve Degeneration; Neurons/pathology; Substantia Innominata/*pathology
AD Department of Neurological Sciences, Facultad de Medicina, Universidad de Chile, Santiago de Chile.
SP englisch
PO England