NR ACHQ
AU Cashman,N.R.
TI A prion primer
QU CMAJ. Canadian Medical Association Journal 1997 Nov 15; 157(10): 1381-5
KI CMAJ. 1998 Feb 10;158(3):302-3. PMID: 9484252 CMAJ. 1998 Mar 24;158(6):718. PMID: 9546874
PT journal article; review; review, tutorial
AB By biological and medical criteria, prions are infectious agents; however, many of their properties differ profoundly from those of conventional microbes. Prions are "encoded" by alterations in protein conformation rather than in nucleic acid or amino acid sequence. New epidemic prion diseases (bovine spongiform encephalopathy and new variant Creutzfeldt-Jakob disease) have recently emerged under the active surveillance of the modern world. The risk of contracting prion disease from blood products or other biologicals is now a focus of worldwide concern. Much has been discovered about prions and prion diseases, but much remains to be done.
ZR 24
MH Blood Transfusion/adverse effects; Great Britain/epidemiology; Human; Prion Diseases/diagnosis/epidemiology/*microbiology/transmission; Prions/chemistry/*pathogenicity; Risk Factors; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; World Health
AD Montreal Neurological Institute and Hospital, McGill University, Que. mdnc@musica.mcgill.ca
SP englisch
PO Kanada