NR ACJI
AU Caughey,B.W.
TI Interactions between prion protein isoforms: the kiss of death?
QU Trends in Biochemical Sciences 2001 Apr; 26(4): 235-42
PT journal article; review; review, tutorial
AB Direct interactions between the normal and aberrant forms of prion protein appear to be crucial in the transmission and pathogenesis of transmissible spongiform encephalopathies (TSEs) or prion diseases. Recent studies of such interactions in vitro have provided mechanistic insight into how TSE-associated prion protein might promote its own propagation in a manner that is specific enough to account, at least in part, for TSE strains and species barriers.
ZR 42
MH Prion Diseases/metabolism; Prions/*metabolism; Protein Binding; Protein Isoforms/*metabolism
AD Laboratory of Persistent Viral Diseases, NIAID, NIH, Rocky Mountain Laboratories, 903 S. 4th St, 59840, Hamilton, MT, USA. bcaughey@nih.gov
SP englisch
PO England