NR ACJW
AU Caughey,B.W.; Ernst,D.; Race,R.E.
TI Congo red inhibition of scrapie agent replication
QU Journal of Virology 1993 Oct; 67(10): 6270-2
PT journal article
AB Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.
MH Animal; Comparative Study; Congo Red/*toxicity; Membrane Glycoproteins/biosynthesis; Mice; Neuroblastoma; PrPsc Proteins; Prions/*biosynthesis/*drug effects/isolation & purification; Tumor Cells, Cultured; Virus Replication/*drug effects
AD Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840.
SP englisch
PO USA