NR ACLE
AU Cervenakova,L.; Brown,P.; Hammond,D.J.; Lee,C.A.; Saenko,E.L.
TI Factor VIII and transmissible spongiform encephalopathy: the case for safety.
QU Haemophilia 2002 Mar; 8(2): 63-75
PT journal article
AB Haemophilia A is the most common inherited bleeding disorder, caused by a deficiency in coagulation factor VIII (FVIII). Current treatment of haemophilia A is based on repeated infusions of plasma-derived FVIII concentrate or of recombinant FVIII, which may be exposed to plasma-derived material of human or animal origin used in its tissue culture production process. We review epidemiological and experimental studies relevant to blood infectivity in the transmissible spongiform encephalopathies (TSEs, or 'prion' diseases), and evaluate the hypothetical risk of TSE transmission through treatment with plasma-derived or recombinant FVIII.
AD J. Holland Laboratory, American Red Cross, Rockville, MD, USA, NINDS, NIH, Bethesda, MD, USA, Haemophilia Centre and Haemostasis Unit, Royal Free Hospital, London, UK
SP englisch
PO England