NR ACML
AU Chany,C.
TI Involvement of temperature sensitive syncytium inducing VSV or defective retroviruses in the development of spongiform encephalopathies
QU Biomedicine and Pharmacotherapy 1997; 51(10): 446-8
PT journal article
AB Various enveloped viruses can induce syncytia in competent cells. Some temperature-sensitive mutants can express the trans-membrane viral G antigen under non-permissive conditions. The G antigen can then migrate at long distances, engulfing thousands of cells without producing any virus. When a temperature-sensitive vesicular stomatitis virus (VSV) infects a sensitive host, and under the condition that the G antigen is expressed, spongiosis can be induced in the central nervous system in the absence of detectable virus multiplication. We postulate that such a mechanism might be observed with various enveloped viruses, as recently illustrated with knock-out mice experimentally infected with defective murine leukemia virus (MULV).
MH Animal; Brain/*pathology/virology; Defective Viruses/*physiology; Giant Cells; Human; Mice; Models, Biological; Prion Diseases/pathology/*physiopathology/virology; Retroviridae/*physiology; Vesicular stomatitis-Indiana virus/*physiology
AD Laboratory of Cellular Physiology, University Pierre and Marie Curie, Paris, France.
SP englisch
PO Frankreich