NR ACNT
AU Chen,S.G.; Gambetti,P.
TI A journey through the species barrier
QU Neuron 2002 Jun 13; 34(6): 854-6
KZ Neuron. 2002 Jun 13;34(6):921-32. PMID: 12086640
PT comment; journal article
AB The species barrier in prion infectivity is believed to reside in the degree of amino acid sequence heterology between the infectious prion protein, PrPsc, of the donor and the normal PrP of the host. bring new evidence that distinct PrPsc species or prion strains may have different conformations even when they have identical amino acid sequence and that the conformation of the exogenous prion strain is a determinant of the species barrier in hosts that have identical PrP genotype.
MH Animal; Human; Prion Diseases/etiology/metabolism; Prions/*chemistry/pathogenicity; Protein Conformation; Species Specificity
AD Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
SP englisch
PO USA