NR ACPH
AU Cho,H.J.
TI Requirement of a protein component for scrapie infectivity
QU Intervirology 1980; 14(3-4): 213-6
PT journal article
AB Scrapie infectivity in the Hirt supernatant of a 20% scrapie-infected mouse brain filtrate was almost totally inactivated by pronase treatment. It was not affected by RNase A treatment and was only slightly reduced by DNase I treatment. These results indicate that a protein component is required for the transfection of scrapie nucleic acid and that free scrapie nucleic acid is either not infectious or its infectivity is extremely low.
MH Animal; DNA, Viral/genetics; Peptide Hydrolases; Prions/*analysis; Scrapie/*microbiology; Sheep; Viral Proteins/*physiology
SP englisch
PO Schweiz