NR ACQD
AU Chung,Y.L.; Williams,A.; Ritchie,D.; Williams,S.C.R.; Changani,K.K.; Hope,J.; Bell,J.D.
TI Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases
QU Neuroreport 1999 Nov 26; 10(17): 3471-7
KI Neuroreport. 2000 Nov 27;11(17):L5-6. PMID: 11117520
PT journal article
AB Magnetic resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt-Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology. Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and hyper-intense changes in the conventional T2-weighted MR images, respectively. These opposing effects were shown to give rise to normal images of a scrapie-affected brain undergoing severe neurodegeneration, and may underlie the variability of previous CJD MRI data.
MH Animal; Brain/*pathology; Creutzfeldt-Jakob Syndrome/pathology; Disease Models, Animal; Glial Fibrillary Acidic Protein/analysis; Gliosis/*pathology; Hamsters; Magnetic Resonance Imaging; Neurons/*pathology; Scrapie/diagnosis/*pathology; Support, Non-U.S. Gov't
AD Robert Steiner Magnetic Resonance Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
SP englisch
PO England