NR ACQG
AU Chung,Y.L.; Williams,A.; Beech,J.S.; Williams,S.C.R.; Bell,J.D.; Cox,I.J.; Hope,J.
TI MRI assessment of the blood-brain barrier in a hamster model of scrapie
QU Neurodegeneration. A Journal for neurodegenerative Disorders, Neuroprotection, and Neuroregeneration 1995 Jun; 4(2): 203-7
PT journal article
AB Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.
IN Bei an Scrapie erkrankten Hamstern wurde festgestellt, dass ihre Bluthirnschranke zusammengebrochen war.
MH Animal; Blood-Brain Barrier/*physiology; Disease Models, Animal; Evaluation Studies; Gadolinium; Gadolinium DTPA; Hamsters; *Magnetic Resonance Imaging; Organometallic Compounds; Pentetic Acid/analogs & derivatives; Protons; Scrapie/*diagnosis; Support, Non-U.S. Gov't
AD Robert Steiner MR Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London.
SP englisch
PO England
OR Prion-Krankheiten C