NR ACRS
AU Cochius,J.I.; Hyman,N.; Esiri,M.M.
TI Creutzfeldt-Jakob disease in a recipient of human pituitary-derived gonadotrophin: a second case.
QU Journal of Neurology, Neurosurgery and Psychiatry 1992 Nov; 55(11): 1094-5
PT journal article
AB A 44 year old female presented with a progressive cerebellar disturbance approximately 13 years after receiving human pituitary derived gonadotrophin injections as a treatment for infertility. The patient died approximately nine months later. Creutzfeldt-Jakob disease was confirmed at necropsy. This is the second reported case of Creutzfeldt-Jakob disease in a recipient of human derived gonadotrophin.
IN Eine 44 Jahre alte Patientin zeigte etwa 13 Jahre nach einer Unfruchtbarkeitsbehandlung mit aus menschlichen Hirnanhangdrüsen (Hypophysen) gewonnenem Gonadotropin zunehmende Kleinhirnstörungen und starb nach 9 Monaten an neuropathologisch bestätigter Creutzfeldt-Jakob-Krankheit.
MH Adult; Autopsy; Case Report; Cerebellum/ultrastructure; Creutzfeldt-Jakob Syndrome/*chemically induced; Epilepsies, Myoclonic/chemically induced; Female; Gonadotropins, Pituitary/*adverse effects/therapeutic use; Human; Infertility, Female/*drug therapy; Temporal Lobe/ultrastructure
AD Department of Neurology, Radcliffe Infirmary, Oxford, UK
SP englisch
PO England