NR ACRZ
AU Coe,J.E.; Race,R.E.; Ross,M.J.
TI Serological evidence for an inflammatory response in murine scrapie
QU Journal of Infectious Diseases 2001 Jan 15; 183(2): 185-191
PT journal article
AB Transmissible spongiform encephalopathies (TSEs) are initiated by a novel kind of agent that produces characteristic degenerative changes in the brain without a detectable systemic inflammatory response or serological changes. A murine scrapie model was evaluated for changes in plasma concentration of serum amyloid P component (SAP), a protein that is up-regulated in infected and/or injured mice during the acute phase response (APR). C57BL10 and IRW mice inoculated with scrapie brain developed clinical scrapie 125-150 days later. At this time, concentration of plasma SAP increased in most of them. The SAP level increased > or =3-fold in >80% of the scrapie-affected C57BL10 mice and IRW male mice. A similar increase was found in <3% of respective nonscrapie control mice. The up-regulation of mouse SAP during clinical scrapie provides evidence for the activation of a systemic APR in TSE, a serological change that may be clinically useful.
MH *Acute-Phase Reaction; Amyloid P Component/*analysis; Animal; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Scrapie/*blood/*pathology
AD Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA. jcoe@niaid.nih.gov
SP englisch
PO USA