NR ACSK

AU Cohen,F.E.

TI Protein misfolding and prion diseases

QU Journal of Molecular Biology 1999 Oct 22; 293(2): 313-20

PT journal article; review; review, tutorial

AB The prion diseases provide an intriguing connection between protein folding and neurodegenerative disease. In this review, I explore that importance of protein folding and misfolding in the prion diseases. Thermodynamic and kinetic models are examined in an effort to understand infectious, inherited and sporadic forms of these diseases. These concepts can be generalized to gain insight into other disorders of protein aggregation and deposition such as Alzheimer's disease.

ZR 62

MH Animal; Human; Kinetics; Prion Diseases/genetics/*metabolism; Prions/*chemistry/genetics/*metabolism; *Protein Folding; Protein Structure, Secondary; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Thermodynamics

AD Fred E. Cohen (cohen@cgl.ucsf.edu), Cellular and Molecular Pharmacology, Biochemistry and Biophysics, and Medicine, University of California, 513 Parnassus Avenue, San Francisco, CA 94143-0450, USA

SP englisch

PO England

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