NR ACTL
AU Colling,S.B.; Collinge,J.; Jefferys,J.G.R.
TI Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents.
QU Neuroscience Letters 1996 May 3; 209(1): 49-52
PT journal article
AB The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice.
MH Action Potentials; Analysis of Variance; Animal; Calcium/*pharmacology; Charybdotoxin/pharmacology; Crosses, Genetic; Female; Hippocampus/*physiology; In Vitro; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Potassium Channels/drug effects/*physiology; Prions/*genetics; Pyramidal Cells/drug effects/*physiology; Recombination, Genetic; Support, Non-U.S. Gov't
AD Department of Physiology and Biophysics, St Mary's Hospital Medical School, Imperial College, London, UK
SP englisch
PO Irland
OR Prion-Krankheiten C