NR ACUF
AU Collinge,J.; Palmer,M.S.
TI Prion diseases
QU Current Opinion in Genetics and Development 1992 Jun; 2(3): 448-54
PT journal article; review; review, tutorial
AB There have been remarkably rapid advances in the understanding of prion diseases over the past year. The controversial notion that the transmissible agent may be an abnormal isoform of a host-encoded protein, the prion protein, is now gaining wide acceptance. The conundrum of how a disease can both be inherited as an autosomal dominant condition and also be experimentally transmissible by inoculation is beginning to make sense.
ZR 36
MH Animal; Human; Prions/biosynthesis/chemistry; Slow Virus Diseases/*genetics
AD Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London, UK
SP englisch
PO England