NR ACUN
AU Collins,S.J.; Boyd,A.; Fletcher,A.; Kaldor,J.; Hill,A.; Farish,S.; McLean,C.; Ansari,Z.; Smith,M.; Masters,C.L.
TI Creutzfeldt-Jakob disease cluster in an Australian rural city
QU Annals of Neurology 2002 Jul; 52(1): 115-8
PT journal article
AB Through the Australian National Creutzfeldt-Jakob Disease Registry, 6 pathologically confirmed sporadic cases were recognized over a 13-year period in persons who had been long-term residents of a moderate-sized rural city, whereas the expected number was 0.923. An extensive investigation could not find any point-source or case-to-case transmission links. This occurrence is highly statistically significant (p = 0.0027) when viewed in isolation and remains significant (p < 0.02) when only the cases that arose after the cluster was recognized were taken into account. However, a more conservative statistical analysis suggests that such a grouping could have arisen by chance in at least one population group of this size when the whole country is taken into consideration.
MH Aged; Australia/epidemiology; Cluster Analysis; Creutzfeldt-Jakob Syndrome/*epidemiology; Female; Human; Male; Middle Age; Poisson Distribution; Registries/statistics & numerical data; *Rural Population/statistics & numerical data; Support, Non-U.S. Gov't
AD
Steven Collins, MD 1 2, Alison Boyd, Post Grad Dip Gen Coun 1 2, Ashley Fletcher, BSc 1 2, John Kaldor, PhD 3, Andrew Hill, PhD 2, Stephen Farish, MEd 4, Catriona McLean, MD 1 2, Zahid Ansari, MPH 5, Margaret Smith, BSc 2 6, Colin L. Masters, MD 1 2
1Australian National Creutzfeldt-Jakob Disease Registry, University of Melbourne, Victoria, Australia
2Department of Pathology, University of Melbourne, Victoria, Australia
3National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, New South Wales, Australia
4Epidemiology and Biostatistics Unit, School of Population Health, University of Melbourne, Melbourne, Australia
5Health Outcomes Section, Public Health Division, Department of Human Services, Melbourne, Australia
6Molecular Biology Laboratory, Melbourne Health Shared Pathology Services, Royal Melbourne Hospital, Parkville, Victoria, Australia
email: Steven Collins (stevenjc@unimelb.edu.au)
SP englisch
PO USA