NR ACVF
AU Combarros,O.; Sanchez-Guerra,M.; Llorca,J.; Alvarez-Arcaya,A.; Berciano,J.; Pena,N.; Fernandez-Viadero,C.
TI Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD
QU Neurology 2000 Aug 22; 55(4): 593-5
PT journal article
AB An association between cognitive performance in elderly people and variability in the codon 129 of the prion protein gene (PRNP) has been recently described. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE genotype, age, and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine alleles and AD.
MH Age of Onset; Aged; Aged, 80 and over; Alleles; Alzheimer Disease/epidemiology/*genetics; Amino Acid Substitution/genetics; Amyloid/*genetics; Apolipoproteins E/genetics; Caucasoid Race/genetics; Female; Genetic Predisposition to Disease/epidemiology; Heterozygote Detection; Homozygote; Human; Linkage (Genetics)/genetics; Male; Middle Age; Odds Ratio; Polymorphism (Genetics)/*genetics; Protein Precursors/*genetics; Risk Assessment; Spain/epidemiology
AD Service of Neurology, University Hospital Marques de Valdecilla, Santander, Spain. neuro@humv.es
SP englisch
PO USA