NR ACWZ
AU Coulthart,M.B.; Cashman,N.R.
TI Variant Creutzfeldt-Jakob disease: a summary of current scientific knowledge in relation to public health.
QU CMAJ. Canadian Medical Association Journal 2001 Jul 10; 165(1): 51-8
PT journal article; review; review literature
AB The prion diseases pose unique scientific, medical, veterinary and regulatory challenges. Here, we summarize current information bearing on the natural history, pathobiology and epidemiology of these disorders and public policy responses to the potential threats to public health posed, particularly, by bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease (vCJD). Six years after the first case reports of vCJD, there is still no clear indication of the magnitude of the primary epidemic, or of the likelihood of lateral transmission of this untreatable disease by iatrogenic means, particularly by blood and blood products. However, the unsettling nature of the available evidence warrants prudence regarding public health policy and regulation, as well as a forward-looking approach to research.
ZR 89
MH Animal; Cattle; *Creutzfeldt-Jakob Syndrome/diagnosis/epidemiology/etiology/transmission; Disease Outbreaks; Encephalopathy, Bovine Spongiform/epidemiology/transmission; Great Britain/epidemiology; Health Policy; Human; Incidence; Population Surveillance; *Public Health; Zoonoses
AD National Laboratory for Host Genetics and Prion Diseases, Canadian Science Centre for Human and Animal Health, Health Canada, Winnipeg, Man. mike_coulthart@hc-sc.gc.ca
SP englisch
PO Kanada