NR ADAW
AU Davanipour,Z.; Alter,M.; Sobel,E.; Asher,D.M.; Gajdusek,D.C.
TI Transmissible virus dementia: evaluation of a zoonotic hypothesis.
QU Neuroepidemiology 1986; 5(4): 194-206
PT journal article
AB Creutzfeldt-Jakob disease (CJD) and kuru are subacute transmissible dementing encephalopathies characterized by spongiform changes in the brain. Scrapie is a similar slow viral encephalopathy which affects sheep, goats and certain other animals. Anecdotal reports suggest that Creutzfeldt-Jakob disease could be a zoonosis. To evaluate the possibility that CJD is acquired from animals, a case-control study was conducted on 26 well-documented CJD cases and 40 controls. Data were collected on exposure to animals through occupations, hobbies, sports and pets. An excess exposure to certain animals was noted among the patients compared to controls in relation to occupation (deer, monkey, squirrel; odds ratio (OR) = 8.9; p less than 0.10) and hobbies (deer, OR = 9.0; rabbit, OR = 6.0; p less than 0.05). Similarly, exposure to animal organs was significantly greater in the CJD group (OR = 20.9; p less than 0.005). Statistically significant increased exposure to sheep or goats was not found among the patients. However, since spongiform encephalopathy has a wider host range than sheep and goats, the increased exposure to certain other animals suggests that a zoonotic source for CJD should be further explored.
IN Bei 20 CJD-Patienten wurde signifikant häufiger Kontakt zu Hirschen, Affen oder Eichhörnchen beobachtet, als bei 40 Kontrollpersonen. Ein Zusammenhang mit Schafen oder Ziegen wurde nicht festgestellt. Laut [ADAX] handelt es sich seltsamerweise bei den Kontrollpersonen ausgerechnet um Krankenhauspatienten.
MH Adult; Aged; Animal; Creutzfeldt-Jakob Syndrome/epidemiology/*etiology; Female; Human; Male; Middle Age; Virus Diseases/transmission/*veterinary; Zoonoses/*transmission
SP englisch
PO Schweiz
OR Prion-Krankheiten D