NR ADCI
AU de Reuck,J.; de Coster,W.; Otte,G.; vander Eecken,H.
TI Papova virus-like particles in a nigral type of Creutzfeldt-Jakob disease
QU Journal of Neurology. Zeitschrift für Neurologie 1976 Sep; 213(3): 179-88
PT journal article
AB In this case of Cruetzfeldt-Jakob disease cortical biopsy demonstrated a large number of papova virus-like particles in the axons, dendrites, astroyctic processes and blood-vessel walls, while necropsy findings disclosed a striking status spongiosus and neuronal degeneration in the substantia nigra. The patient also suffered from a testicular feminization syndrome and was treated with immunosuppressive drugs for pemphigus vulgaris. The ready demonstration of viral particles, the rapid course of the disease and the unusual necropsy findings are discussed and related to the pre-existing diseases of the patient.
MH Case Report; Cerebral Cortex/microbiology/ultrastructure; Creutzfeldt-Jakob Syndrome/etiology/*microbiology/pathology; Female; Human; Immunosuppressive Agents/adverse effects; *Inclusion Bodies, Viral; Middle Age; Papillomaviridae/*isolation & purification; *Polyomaviridae; Substantia Nigra/pathology
AD J.de Reuck, W.de Coster, G.Otte, H.vander Eecken, Departments of Neurology and Pathology, University of Ghent, Belgium
SP englisch
PO Westdeutschland