NR ADCX
AU Dealler,S.F.
TI The key must fit: macrophages transport prion infection to the central nervous system and may determine the sites of infection within it.
QU Medical Hypotheses 1997 Sep; 49(3): 213-20
PT journal article; review; review, tutorial
AB It is suggested that the agent for transmissible spongiform encephalopathies is transferred from an original peripheral site of infection into the brain by recruited and selected circulating macrophages/monocytes. It is because of this selection that strains of disease appear to be different when infecting separate species, but retain characteristics when infecting a single species.
ZR 68
MH Animal; Brain/physiopathology; Brain Diseases/*physiopathology; Human; Lymphocytes/physiology; Macrophages/*physiology; Mice; Mice, Nude; Microglia/*physiology; Models, Biological; Prion Diseases/*physiopathology; Prions/*metabolism; Scrapie/physiopathology/transmission
AD Burnley General Hospital, UK
SP englisch
PO England